An overview of Monascus fermentation processes for monacolin K production
نویسندگان
چکیده
منابع مشابه
Development of monacolin K-enriched ganghwayakssuk (Artemisia princeps Pamp.) by fermentation with Monascus pilosus.
Monacolin K-enriched ganghwayakssuk (Artemisia princeps Pamp.) was developed by fermentation with Monascus sp. Among the 15 Monascus spp. isolated previously from Monascus fermentation products, Monascus pilosus KMU108 produced 2,219 mg/kg of monacolin K during ganghwayakssuk fermentation with no detectable citrinin. The optimum concentrations of ganghwayakssuk and glucose determined from the r...
متن کاملCloning and Characterization of Monacolin K Biosynthetic Gene Cluster from <italic>Monascus pilosus</italic>
Monacolin K is a secondary metabolite synthesized by polyketide synthases (PKS) from Monascus, and it has the same structure as lovastatin, which is mainly produced by Aspergillus terreus. In the present study, a bacterial artificial chromosome (BAC) clone, mps01, was screened from the BAC library constructed from Monascus pilosus BCRC38072 genomic DNA. The putative monacolin K biosynthetic gen...
متن کاملElevated yield of monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiCl.
In China, Monascus spp., a traditional fungus used in fermentation, is used as a natural food additive. Monascus spp. can produce a secondary metabolite, monacolin K namely, which is proven to be a cholesterol-lowering and hypotensive agent. Hence, recently, many researchers have begun focusing on how to increase the production of monacolin K by Monascus purpureus. In the present study, we inve...
متن کاملBiosynthesis of monacolins: conversion of monacolin L to monacolin J by a monooxygenase of Monascus ruber.
The microbial metabolites monacolins J and L are specific inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme in cholesterol synthesis. The producing strain Monascus ruber M 4681 was found to convert exogenously added monacolin L to J. In this hydroxylation reaction 18O2 was incorporated into monacolin L, giving [18O]-monacolin J. The cell-free extracts of M. ruber ...
متن کاملMonacolin K, a new hypocholesterolemic agent produced by a Monascus species.
Sir: In previous papers from our laboratory, ML236B, a metabolite of Penicillium citrinum that was isolated as an inhibitor of cholesterol synthesis1), was shown to have hypocholesterolemic activity in several animal species2,3). Further work in this laboratory to search for microbial metabolites having cholesterol-lowering activity led to the isolation of a new active compound (designated as m...
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ژورنال
عنوان ژورنال: Open Chemistry
سال: 2020
ISSN: 2391-5420
DOI: 10.1515/chem-2020-0006